Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Florenc | Brussels-South (Gare du Midi) | CheapestFastest |
Last refresh of the prices: Today at 2:19 PM CEST.
Compare 2 ways to go from Prague to Brussels
Among the sustainable travel choices, the Train stands out as a good way to reach Brussels. The journey takes about 15 hours 22 minutes and with fares starting at just $81, it presents an excellent value for a comfortable ride.
Where are the popular stops in Prague and Brussels?
Stops in Prague
- AKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- BAviatická, 161 08, Praha 6, Czechia
- C
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - DChlumecká, 198 00 Praha 20, Czech Republic
- ETomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- F300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - DPachecolaan 5, 1000 Brussel, Belgium
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Frequently asked questions about traveling from Prague to Brussels by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Prague to Brussels?
The cheapest bus tickets from Prague to Brussels start from $45. The average price for this route is around $87. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Brussels?
The average bus trip duration from Prague to Brussels is 18h 25m, covering a distance of 443 miles (713 km). The quickest bus can get you there in 12h and is operated by RegioJet.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 17 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 1:45am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus trip from Prague to Brussels generates an estimated 17.82395 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1074 reviews.
Which bus company has the best Wi-Fi from Prague to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Prague to Brussels?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Brussels was searched and found on May 11, 2026 with a price of $58To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.
You can expect to pay from $58 to $145 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $58 which is on 2026-05-11.
What's the cheapest way to go from Prague to Brussels?
The Bus is the cheapest travel choice for this destination
